Short Cut Keys 

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WinKey + D = Minimizes all windows and shows the desktop
WinKey + L = Locks the computer (Windows XP only)
WinKey + Tab = Cycles through the programs shown on the taskbar
WinKey + F = Brings up the Windows Search box
WinKey+E = Opens up Windows Explorer
WinKey + R = Opens the Run dialog box
WinKey + Pause = Opens System Properties

Using the keyboard, you might find these useful.

SHIFT+F10 = Same as right-clicking an object
CTRL+ESC = Opens the Start menu
SHIFT = Press and hold down the SHIFT key while you insert a CD-ROM to bypass the auto-run feature
ALT+underlined
letter in menu = Opens the menu
ALT+F4 = Closes the current program
CTRL+F4 = Closes the current window in a program
ALT+F6 = Switches between multiple windows in the same program
CTRL+Tab = Switches between multiple tabbed windows in the same program
SHIFT+DELETE = Deletes selection immediately, without it hitting the Recycle Bin

Here are some shortcuts for Microsoft Word.
Ctrl + 1 = Highlighted area single line space
Ctrl + .5 = Highlighted area 1 1/2 line space
Ctrl + 2 = Highlighted area double line space
Ctrl + A = Selects all the contents of a page
Ctrl + C = Copy selected text
Ctrl + X = Cut selected text
Ctrl + V = Paste the selected text
Ctrl + F = Opens the find box
Ctrl + B = Bolds the highlighted selection
Ctrl + I = Italicize the highlighted selection
Ctrl + K = Insert a link to a Web site
Ctrl + U = Underline the highlighted selection
Ctrl + Y = Repeat the last action performed
Ctrl + Z = Undo last action (I love this one!)
Ctrl + End = Moves the cursor to the end of the document
Ctrl + Home = Moves the cursor to the beginning of the document

And when you do need to use the mouse, here are some shortcuts for it.

Double-click = Selects a word
Triple-click = Selects a paragraph
Ctrl + Mouse wheel = Use it when you want to zoom in and out of what is showing on the screen
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Browse Location of lots of icons: C:Windows\system32\shell32.dll